부산대학교 도서관

Simple Summary: A low prognostic nutritional index (PNI) is linked to poor survival in patients with nasopharyngeal carcinoma (NPC), but existing research primarily examines the pre- or post-treatment PNI at single timepoints. Our study employs joint modeling to investigate the relationship between longitudinal PNI data from routine visits and overall survival. This approach addresses biases inherent in traditional time-varying covariate Cox models. Our findings indicate that decreased PNI levels during follow-up correlate with a reduced overall survival. Specifically, a post-treatment PNI below 38.1 markedly increases the risk of 90-day mortality. This emphasizes the importance of routine longitudinal PNI data in predicting survival outcomes for patients with NPC, offering a comprehensive perspective compared to isolated timepoint measurements. Background: a low PNI in patients with NPC is linked to poor survival, but prior studies have focused on single-timepoint measurements. Our study aims to employ joint modeling to analyze longitudinal PNI data from each routine visit, exploring its relationship with overall survival. Methods: In this retrospective study using data from the Chang Gung Research Database (2007–2019), we enrolled patients with NPC undergoing curative treatment. We analyzed the correlation between patient characteristics, including the PNI, and overall survival. A joint model combining a longitudinal sub-model with a time-to-event sub-model was used to further evaluate the prognostic value of longitudinal PNI. Results: A total of 2332 patient were enrolled for the analysis. Separate survival analyses showed that longitudinal PNI was an independent indicator of a reduced mortality risk (adjusted HR 0.813; 95% CI, 0.805 to 0.821). Joint modeling confirmed longitudinal PNI as a consistent predictor of survival (HR 0.864; 95% CI, 0.850 to 0.879). An ROC analysis revealed that a PNI below 38.1 significantly increased the risk of 90-day mortality, with 90.0% sensitivity and 89.6% specificity. Conclusions: Longitudinal PNI data independently predicted the overall survival in patients with NPC, significantly forecasting 90-day survival outcomes. We recommend routine PNI assessments during each clinic visit for these patients. [ABSTRACT FROM AUTHOR]