부산대학교 도서관

To examine whether efficacy of postoperative oral administration of UFT, a 5-fluorouracil derivative chemotherapeutic agent, may be influenced by incidence of apoptosis (apoptosis index) or apoptosis-related gene status (p53 andbcl-2) of the tumour, a total of 162 patients with pathologic stage I non-small cell lung cancer were retrospectively reviewed. UFT was administrated postoperatively to 44 patients (UFT group), and not to the other 118 patients (Control group). For all patients, 5-year survival rate of the UFT group (79.9%) seemed higher than that of the Control group (69.8%), although without significant difference (P = 0.054). For patients with higher apoptotic index, 5-year survival rate of the UFT group (83.3%) was significantly higher than that of the Control group (67.6%,P = 0.039); for patients with lower apoptotic index, however, there was no difference in the prognosis between these two groups. Similarly, UFT was effective for patients withoutp53 aberrant expression (5-year survival rates: 95.2% for the UFT group and 74.3% for the Control group,P = 0.022), whereas not effective for patients withp53 aberrant expression.Bcl-2 status did not influence the efficacy of UFT. In conclusion, apoptotic index andp53 status are useful factors to predict the efficacy of postoperative adjuvant therapy using UFT. [ABSTRACT FROM AUTHOR]