부산대학교 도서관

Standardized Ginkgo biloba extract EGb 761 exhibits beneficial effects to patients with Alzheimer's disease (AD). It was previously demonstrated EGb 761 inhibits amyloid beta (Aβ) oligomerization vitro, protects neuronal cells against Aβ toxicity, and improves cognitive defects in a mouse model of AD 2576). In this study, the neurogenic potential of EGb 761 and its effect on cAMP response element binding protein (CREB) were examined in a double transgenic mouse model (TgAPP/PS1). EGb 761 significantly increases cell proliferation in the hippocampus of both young (6 months) and old (22 months) TgAPP/ mice, and the total number of neuronal precursor cells in vitro in a dose-dependent manner. Furthermore, Aβ oligomers inhibit phosphorylation of CREB and proliferation in the hippocampus of TgAPP/PS1 mice. Administration of EGb 761 reduces Aβ oligomers restores CREB phosphorylation in the hippocampus these mice. The present findings suggest that 1) enhanced neurogenesis by EGb 761 may be mediated activation of CREB, 2) stimulation of neurogenesis EGb 761 may contribute to its beneficial effects in patients and improved cognitive functions in the mouse model of AD, and 3) EGb 761 has therapeutic potential for the prevention and improved treatment of AD. [ABSTRACT FROM AUTHOR]