학술논문
A Mouse Model of Atrial Fibrillation in Sepsis.
Document Type
Article
Author
Source
Subject
*ATRIAL fibrillation
*BODY surface mapping
*LABORATORY mice
*SEPSIS
*ARRHYTHMIA
*ANIMAL disease models
*ATRIAL flutter
*ACTION potentials
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Language
ISSN
0009-7322
Abstract
Here, we introduce a mouse model of sepsis-related AF caused by CLP and mediated by altered atrial electrophysiology associated with dysregulated expression of conduction-related genes and atrial inflammation. KN-93 treatment significantly reduced AF inducibility in CLP-treated mice, suggesting that CaMKII activation is necessary for sepsis-related atrial arrhythmogenesis (]). Keywords: animal disease models; atrial fibrillation; cardiac arrhythmias; sepsis EN animal disease models atrial fibrillation cardiac arrhythmias sepsis 1047 1049 3 03/27/23 20230328 NES 230328 Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with associated morbidity and mortality including stroke, dementia, congestive heart failure, and death. Animal disease models, atrial fibrillation, cardiac arrhythmias, sepsis. [Extracted from the article]