학술논문
Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy With High‐Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti–Melanoma Differentiation–Associated Gene 5–Positive Dermatomyositis
Document Type
Article
Author
Tsuji, Hideaki; Nakashima, Ran; Hosono, Yuji; Imura, Yoshitaka; Yagita, Masato; Yoshifuji, Hajime; Hirata, Shintaro; Nojima, Takaki; Sugiyama, Eiji; Hatta, Kazuhiro; Taguchi, Yoshio; Katayama, Masaki; Tanizawa, Kiminobu; Handa, Tomohiro; Uozumi, Ryuji; Akizuki, Shuji; Murakami, Kosaku; Hashimoto, Motomu; Tanaka, Masao; Ohmura, Koichiro
Source
Subject
*AUTOANTIBODIES
*COMBINATION drug therapy
*COMPARATIVE studies
*COMPUTED tomography
*CYTOMEGALOVIRUSES
*DERMATOMYOSITIS
*TACROLIMUS
*GLUCOCORTICOIDS
*IMMUNOSUPPRESSION
*INTERSTITIAL lung diseases
*INTRAVENOUS therapy
*LONGITUDINAL method
*MEDICAL cooperation
*PATIENT safety
*PLASMAPHERESIS
*RESEARCH
*SURVIVAL
*TREATMENT effectiveness
*CYCLOPHOSPHAMIDE
*DESCRIPTIVE statistics
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Language
ISSN
2326-5191
Abstract
Objective: Interstitial lung disease (ILD) accompanied by anti–melanoma differentiation–associated gene 5 (anti–MDA‐5)–positive dermatomyositis (DM) is often rapidly progressive and associated with poor prognosis. Because there is no established treatment, we undertook this study to prospectively evaluate the efficacy and safety of a combined immunosuppressive regimen for anti–MDA‐5–positive DM patients with ILD. Methods: Adult Japanese patients with new‐onset anti–MDA‐5–positive DM with ILD (n = 29) were enrolled at multiple study centers from 2014 to 2017. They were treated with a regimen of high‐dose glucocorticoids (GCs), tacrolimus, and intravenous cyclophosphamide (IV CYC). Plasmapheresis was used if a patient's condition worsened after the regimen started. The primary end point was 6‐month survival, which was compared between this group of patients and a historical control group (n = 15) consisting of anti–MDA‐5–positive DM patients with ILD who received step‐up treatment (high‐dose GC and stepwise addition of immunosuppressant). Secondary end points were 12‐month survival rate, adverse events, and changes in laboratory data. Results: The combined immunosuppressive regimen group showed significantly higher 6‐month survival rates than the step‐up treatment group (89% versus 33%; P < 0.0001). Over a period of 52 weeks, improvements in anti–MDA‐5 titers, serum ferritin levels, vital capacity, and chest high‐resolution computed tomography scores were observed. The combined immunosuppressive regimen group received IV CYC nearly 20 days earlier with shorter intervals and tended to receive plasmapheresis more often than patients undergoing step‐up treatment. Cytomegalovirus reactivation was frequently observed over 52 weeks. Conclusion: A combined immunosuppressive regimen is effective for anti–MDA‐5–positive DM patients with ILD. Plasmapheresis can be used for additional effect in intractable disease. Patients should be carefully monitored for opportunistic infections during treatment. [ABSTRACT FROM AUTHOR]