부산대학교 도서관

Abstract. In December 1975, a patient with varicella was admitted to a ward for children less than 2 years of age. Among 76 children without a history of varicella, 33 children more than 1 year of age were immediately vaccinated with a small viral dose of 80 plaque-forming units per person. Forty-three children less than 1 year of age were left unvaccinated. Among the vaccinated children, only eight exhibited mild varicella, while typical varicella developed in all 43 unvaccinated children during the next ten weeks. In July 1976, another patient with varicella was admitted to a ward with 49 children 3 to 5 years old. The children were immediately given the skin reaction test with inactivated varicella antigen. Seventeen of the 20 children with negative reactions were vaccinated, while the index patient and two children with fever were not vaccinated. Only one of the 17 vaccinated children showed mild varicella symptoms within two weeks after vaccination, while typical varicella developed in two unvaccinated children during the four weeks after appearance of the index case. Varicella developed in none of the 29 children who had positive skin tests. In the sequential skin test of seven vaccinated children, a positive skin reaction was observed as early, as five days after vaccination, which preceded the appearance of neutralization antibody by seven to nine days. [ABSTRACT FROM AUTHOR]