학술논문
Electrochemical Ni‐Catalyzed Decarboxylative C(sp3 )−N Cross‐Electrophile Coupling.
Document Type
Article
Author
Source
Subject
*CARBOXYLIC acid derivatives
*ALKYL radicals
*CARBOXYLIC acids
*FUNCTIONAL groups
*CHEMISTS
*ELECTROPHILES
*ELECTROLYTIC reduction
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Language
ISSN
0044-8249
Abstract
A new electrochemical transformation is presented that enables chemists to couple simple alkyl carboxylic acid derivatives with an electrophilic amine reagent to construct C(sp3)−N bond. The success of this reaction hinges on the merging of cooperative electrochemical reduction with nickel catalysis. The chemistry exhibits a high degree of practicality, showcasing its wide applicability with 1°, 2°, 3° carboxylic acids and remarkable compatibility with diverse functional groups, even in the realm of late‐stage functionalization. Furthermore, extensive mechanistic studies have unveiled the engagement of alkyl radicals and iminyl radicals; and elucidated the multifaceted roles played by iPr2O, Ni catalyst, and electricity. [ABSTRACT FROM AUTHOR]