학술논문
Metallosurfactants C-Cu-C: vesicle formation and its drug-controlled release properties.
Document Type
Article
Author
Source
Subject
*SURFACE active agents
*VESICLES (Cytology)
*ELECTRIC conductivity
*NEGATIVE staining
*DOXORUBICIN
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Language
ISSN
0303-402X
Abstract
Three metallosurfactants C-Cu-C ( n = 8, 12, 16) were synthesized via two-step in this paper. All of these surfactants were characterized by ultimate analysis, H NMR, FT-IR, LC-MS, elemental analysis. In addition, the three surfactants can form vesicles under sonication at a relatively high concentration, and their aggregation behavior and the stability of C-Cu-C vesicles were investigated by surface tension, electrical conductivity, FT-IR, negative staining-TEM. Results showed that C-Cu-C vesicles with average size of ∼60 nm had good stability over inorganic salt, temperature, and aging time. Doxorubicin hydrochloride was incorporated into C-Cu-C vesicles with a remarkably high efficiency of above 70 %, and the delivery system has obvious sustained release effect. [ABSTRACT FROM AUTHOR]