학술논문
A switch-on MRI contrast agent for noninvasive visualization of methylmercury.
Document Type
Article
Source
Subject
*METHYLMERCURY
*CONTRAST media
*NEUROTOXIC agents
*BIO-imaging sensors
*ORGANOMERCURY compounds
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Language
ISSN
1359-7345
Abstract
This communication presents the first Gd(iii)-based T1 MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH3Hg+. o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH3Hg+. Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH3Hg+. Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH3Hg+ and could be useful for biomedical applications. [ABSTRACT FROM AUTHOR]