학술논문
Long-term multiple metabolic abnormalities among healthy and high-risk people following nonsevere COVID-19.
Document Type
Article
Author
Washirasaksiri, Chaiwat; Sayabovorn, Naruemit; Ariyakunaphan, Pinyapat; Kositamongkol, Chayanis; Chaisathaphol, Thanet; Sitasuwan, Tullaya; Tinmanee, Rungsima; Auesomwang, Chonticha; Nimitpunya, Pongpol; Woradetsittichai, Diana; Chayakulkeeree, Methee; Phoompoung, Pakpoom; Mayurasakorn, Korapat; Sookrung, Nitat; Tungtrongchitr, Anchalee; Wanitphakdeedecha, Rungsima; Muangman, Saipin; Senawong, Sansnee; Tangjittipokin, Watip; Sanpawitayakul, Gornmigar
Source
Subject
*COVID-19
*MEDICAL personnel
*HUMAN abnormalities
*C-reactive protein
*COVID-19 vaccines
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Language
ISSN
2045-2322
Abstract
Few studies have identified the metabolic consequences of the post-acute phase of nonsevere COVID-19. This prospective study examined metabolic outcomes and associated factors in nonsevere, RT-PCR-confirmed COVID-19. The participants' metabolic parameters, the prevalence of long-term multiple metabolic abnormalities (≥ 2 components), and factors influencing the prevalence were assessed at 1, 3, and 6 months post-onset. Six hundred individuals (mean age 45.5 ± 14.5 years, 61.7% female, 38% high-risk individuals) with nonsevere COVID-19 attended at least one follow-up visit. The prevalence of worsening metabolic abnormalities was 26.0% for BMI, 43.2% for glucose, 40.5% for LDL-c, 19.1% for liver, and 14.8% for C-reactive protein. Except for lipids, metabolic-component abnormalities were more prevalent in high-risk hosts than in healthy individuals. The prevalence of multiple metabolic abnormalities at the 6-month follow-up was 41.3% and significantly higher in high-risk than healthy hosts (49.2% vs 36.5%; P = 0.007). Factors independently associated with a lower risk of these abnormalities were being female, having dyslipidemia, and receiving at least 3 doses of the COVID-19 vaccine. These findings suggest that multiple metabolic abnormalities are the long-term consequences of COVID-19. For both high-risk and healthy individuals with nonsevere COVID-19, healthcare providers should monitor metabolic profiles, encourage healthy behaviors, and ensure complete vaccination. [ABSTRACT FROM AUTHOR]