부산대학교 도서관

Background: Trachoma is the leading infectious cause of blindness. Repeated or persistent ocular infection with Chlamydia trachomatis in childhood leads to conjunctival scarring, usually in adulthood but often earlier in areas with greater disease burden. There are limited longitudinal data examining change in scarring in children, especially where trachoma rates are low. Methodology/Principal findings: A cohort of children, ages 1–9 years, were randomly selected at baseline from 38 communities in Kongwa, Tanzania and followed for 2 years. Rates of trachomatous inflammation—follicular (TF) were <5% over the survey period. At baseline, 1,496 children were recruited and 1,266 (85%) were followed-up. Photographs were obtained at baseline and follow-up and graded for the presence and severity of scarring using a four-point scale ranging between S1-S4. In children without scarring at baseline, 1.6% (20/1,246) were found to have incident scarring, and incident scarring was more common among girls compared to boys. Among children with scarring at baseline, 21% (4/19) demonstrated progression. Conclusions/Significance: In this formerly hyper-endemic district, the incidence of new scarring in children ages 1–9 years is low, although 21% of those who had scarring at baseline progressed in severity over the 2-year follow-up period. These data provide support for the thesis that while incident scarring more closely reflects ongoing exposure, progression may involve factors independent of ongoing transmission of trachoma. Author summary: Trachoma is the leading infectious cause of blindness. The disease is caused by repeated eye infection with the bacterium Chlamydia trachomatis and characterized clinically in its active stage by follicles (TF) and/or severe inflammation (TI). Scarring of the inner surface of the eyelid results from repeated exposure to infection during childhood, and while active trachoma is mostly observed in childhood, scarring and late complications are often only seen in adulthood. In areas with heavy burden of trachoma, scarring may be observed among children, particularly among those with constant, severe trachoma and/or infection. Few studies have examined the incidence and progression of scarring in children in areas where the prevalence of trachoma has been substantially reduced. In this study, we examined the 2-year incidence and progression of scarring in Kongwa district, Tanzania where the prevalence of TF was about 5%. Incidence of new scarring was 0.8%/year and more common among girls. Progression of scarring was 21% in our cohort of children ages 1–9 years. Incidence in children was low in this formerly hyper-endemic area, but a substantial fraction of those with scarring at baseline demonstrated progression over the follow-up period. These data provide support for the thesis that without repeated exposure to trachoma, incident scarring is low, but other mechanisms for progression of scarring apart from ongoing transmission are operating, at least in children. [ABSTRACT FROM AUTHOR]