학술논문
Exosomes, microvesicles, and other extracellular vesicles—a Keystone Symposia report.
Document Type
Article
Author
Cable, Jennifer; Witwer, Kenneth W.; Coffey, Robert J.; Milosavljevic, Aleksandar; von Lersner, Ariana K.; Jimenez, Lizandra; Pucci, Ferdinando; Barr, Maureen M.; Dekker, Niek; Barman, Bahnisikha; Humphrys, Daniel; Williams, Justin; de Palma, Michele; Guo, Wei; Bastos, Nuno; Hill, Andrew F.; Levy, Efrat; Hantak, Michael P.; Crewe, Clair; Aikawa, Elena
Source
Subject
*EXTRACELLULAR vesicles
*EXOSOMES
*BILAYER lipid membranes
*CONFERENCES & conventions
*PHYSIOLOGY
*PROGNOSIS
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Language
ISSN
0077-8923
Abstract
Extracellular vesicles (EVs) are small, lipid‐bilayer‐bound particles released by cells that can contain important bioactive molecules, including lipids, RNAs, and proteins. Once released in the extracellular environment, EVs can act as messengers locally as well as to distant tissues to coordinate tissue homeostasis and systemic responses. There is a growing interest in not only understanding the physiology of EVs as signaling particles but also leveraging them as minimally invasive diagnostic and prognostic biomarkers (e.g., they can be found in biofluids) and drug‐delivery vehicles. On October 30–November 2, 2022, researchers in the EV field convened for the Keystone symposium "Exosomes, Microvesicles, and Other Extracellular Vesicles" to discuss developing standardized language and methodology, new data on the basic biology of EVs and potential clinical utility, as well as novel technologies to isolate and characterize EVs. [ABSTRACT FROM AUTHOR]