학술논문

A multifaceted architectural framework of the mouse claustrum complex.
Document Type
Article
Source
Journal of Comparative Neurology. Dec2023, Vol. 531 Issue 17, p1772-1795. 24p.
Subject
Language
ISSN
0021-9967
Abstract
Significance Statement: Mice are a highly tractable model for studying the claustrum complex (CLCX). However, without a consensus on how to delineate the CLCX in rodents, comparing results between studies is challenging. It is therefore important to expand our anatomical knowledge of the CLCX, to match the level of detail needed to study its functional properties. To improve and expand upon preexisting delineation schemes, we used the combinatorial expression of several markers to create a comprehensive guide to delineate the CLCX and its subregions, including an online reference atlas. This anatomical framework will allow researchers to anchor future experimental data into a common reference space. We demonstrated the power of this new structural framework by combining our own experimental data with digitally available data on gene expression and input connectivity of the CLCX. [ABSTRACT FROM AUTHOR]