학술논문
Novel Discovery of the Somatostatin Receptor (SSTR2) in Pleomorphic Adenomas via Immunohistochemical Analysis of Tumors of the Salivary Glands.
Document Type
Article
Author
Source
Subject
*SALIVARY gland tumors
*CONFIDENCE intervals
*STAINS & staining (Microscopy)
*PREOPERATIVE period
*IMMUNOHISTOCHEMISTRY
*CELL receptors
*ADENOMA
*RETROSPECTIVE studies
*MAGNETIC resonance imaging
*GENE expression
*SOMATOSTATIN
*GENE expression profiling
*DESCRIPTIVE statistics
*NEUROENDOCRINE tumors
*POSITRON emission tomography
*TUMOR markers
*COMPUTED tomography
*NEUROTRANSMITTER receptors
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Language
ISSN
2072-6694
Abstract
Simple Summary: Currently, the diagnosis of salivary gland tumors using current imaging techniques is unreliable. In this study we examined salivary gland tumors and discovered that the pleomorphic adenoma, a tumor which should be surgically removed because it has a tendency to become malign, has a strong concentration of the somatostatin receptor 2. This characteristic may allow physicians to identify and potentially treat the tumor in a non-invasive manner. Reliable preoperative diagnosis between salivary gland tumor entities is difficult. In this monocentric retrospective study, we examined the somatostatin receptor 2 (SSTR2) status of salivary gland tumors after salivary gland tumor resection via immunohistochemistry (IHC), and stains were compared in analogy to the HER2 mamma scale. A total of 42.3% of all pleomorphic adenoma (PA) tumors (42 of 99, 95% confidence interval 32.5–52.8%) demonstrated ≥20% of cells displaying the SSTR2 as compared to just 1% of all other tumors (1/160, 95% CI 0.02–3.4%). The other tumor was a neuroendocrine carcinoma. PA had a higher intensity of SSTR2 staining, with 90.9% staining ≥ an intensity of 2 (moderate). Tumors with an intensity of SSTR2 expression equal to or greater than 2 had an 89.9% likelihood of being a PA (95% CI: 82.2–95.0%, AUC: 0.928). Only one Warthin tumor demonstrated a 'strong' SSTR2 staining intensity. No Warthin tumor showed a percentage of cells staining for SSTR2 above ≥20%. This result demonstrates consistent and strong expression of SSTR2 in PAs as compared to Warthin tumors, which may allow physicians to utilize radioligand-somatostatin analog PET CT/MR imaging to diagnose the PA. SSTR2 positivity, if shown to be clinically relevant, may allow peptide receptor radionuclide therapy in the future. [ABSTRACT FROM AUTHOR]