학술논문
Genetic ancestry is associated with asthma, and this could be modified by environmental factors. A systematic review.
Document Type
Article
Author
Source
Subject
*WHEEZE
*ASTHMA
*GENEALOGY
*TRANSFORMING growth factors-beta
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Language
ISSN
0954-7894
Abstract
Genetic ancestry is associated with asthma, and this could be modified by environmental factors. Keywords: asthma; country; environment; ethnicity; genetic ancestry EN asthma country environment ethnicity genetic ancestry 668 671 4 06/09/23 20230601 NES 230601 Key messages While Native American genetic ancestry appears protective against asthma, African ancestry increases risk. (B) Asthma risk per 10% increase in African ancestry, among different populations. gl Two of three manuscripts examining European ancestry in Americans reported no association with asthma (a self-identified Hispanic American cohort: OR 1.06, I p i > .05; a self-identified African American cohort: no OR or p value reported). Complex gene-environment interactions contribute to asthma in ethnic populations, highlighting the need for nuanced risk stratification. [Extracted from the article]