학술논문
BIOPHYSICAL MODELING OF TONIC CORTICAL ELECTRICAL ACTIVITY IN ATTENTION DEFICIT HYPERACTIVITY DISORDER.
Document Type
Article
Source
Subject
*ATTENTION-deficit hyperactivity disorder
*DIAGNOSIS of brain diseases
*DENDRITIC cells
*ELECTROENCEPHALOGRAPHY
*THALAMUS
*REACTION time
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Language
ISSN
0020-7454
Abstract
Psychophysiological theories characterize Attention Deficit Hyperactivity Disorder (ADHD) in terms of cortical hypoarousal and a lack of inhibition of irrelevant sensory input, drawing on evidence of abnormal electroencephalographic (EEG) delta–theta activity. To investigate the mechanisms underlying this disorder a biophysical model of the cortex was used to fit and replicate the EEGs from 54 ADHD adolescents and their control subjects. The EEG abnormalities in ADHD were accounted for by the model's neurophysiological parameters as follows: (i) dendritic response times were increased, (ii) intrathalamic activity involving the thalamic reticular nucleus (TRN) was increased, consistent with enhanced delta–theta activity, and (iii) intracortical activity was increased, consistent with slow wave ( [ABSTRACT FROM AUTHOR]