학술논문
Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection.
Document Type
Journal Article
Author
Source
Subject
*SCHISTOSOMA mansoni
*IMMUNE response
*HIV infections
*HIV-positive persons
*IMMUNOGLOBULINS
*HIV infection complications
*ANTHELMINTICS
*ISOQUINOLINE
*ANIMAL experimentation
*ANTIGENS
*COMPARATIVE studies
*CYTOKINES
*HIV
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*SCHISTOSOMIASIS
*TREMATODA
*EVALUATION research
*DISEASE complications
*THERAPEUTICS
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Language
ISSN
0022-1899
Abstract
We show that Ugandan adults coinfected with Schistosoma mansoni and human immunodeficiency virus type 1 (HIV-1) are able to mount S. mansoni-specific immune responses but that few such responses increase after treatment with praziquantel (PZQ). Levels of soluble worm antigen (SWA)-specific immunoglobulin (Ig) G1, IgG2, IgG3, IgG4, interleukin (IL)-4, and IL-5 increased significantly in HIV-negative participants after treatment with PZQ, whereas most soluble egg antigen-specific antibody responses and levels of interferon- gamma were unaltered. Only levels of SWA-specific IL-5 increased in HIV-1-coinfected participants after treatment. These deficiencies in immune responses may account for the previously reported increased susceptibility to infection and reinfection with S. mansoni in individuals coinfected with HIV-1. [ABSTRACT FROM AUTHOR]