학술논문
Rates of respiratory syncytial virus (RSV)-associated hospitalization among adults with congestive heart failure—United States, 2015–2017.
Document Type
Article
Author
Kujawski, Stephanie A.; Whitaker, Michael; Ritchey, Matthew D.; Reingold, Arthur L.; Chai, Shua J.; Anderson, Evan J.; Openo, Kyle P.; Monroe, Maya; Ryan, Patricia; Bye, Erica; Como-Sabetti, Kathryn; Barney, Grant R.; Muse, Alison; Bennett, Nancy M.; Felsen, Christina B.; Thomas, Ann; Crawford, Courtney; Talbot, H. Keipp; Schaffner, William; Gerber, Susan I.
Source
Subject
*CONGESTIVE heart failure
*RESPIRATORY syncytial virus
*AGE groups
*HOSPITAL care
*ADULTS
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Language
ISSN
1932-6203
Abstract
Background: Respiratory syncytial virus (RSV) can cause severe disease in adults with cardiopulmonary conditions, such as congestive heart failure (CHF). We quantified the rate of RSV-associated hospitalization in adults by CHF status using population-based surveillance in the United States. Methods: Population-based surveillance for RSV (RSV-NET) was performed in 35 counties in seven sites during two respiratory seasons (2015–2017) from October 1–April 30. Adults (≥18 years) admitted to a hospital within the surveillance catchment area with laboratory-confirmed RSV identified by clinician-directed testing were included. Presence of underlying CHF was determined by medical chart abstraction. We calculated overall and age-stratified (<65 years and ≥65 years) RSV-associated hospitalization rates by CHF status. Estimates were adjusted for age and the under-detection of RSV. We also report rate differences (RD) and rate ratios (RR) by comparing the rates for those with and without CHF. Results: 2042 hospitalized RSV cases with CHF status recorded were identified. Most (60.2%, n = 1230) were ≥65 years, and 28.3% (n = 577) had CHF. The adjusted RSV hospitalization rate was 26.7 (95% CI: 22.2, 31.8) per 10,000 population in adults with CHF versus 3.3 (95% CI: 3.3, 3.3) per 10,000 in adults without CHF (RR: 8.1, 95% CI: 6.8, 9.7; RD: 23.4, 95% CI: 18.9, 28.5). Adults with CHF had higher rates of RSV-associated hospitalization in both age groups (<65 years and ≥65 years). Adults ≥65 years with CHF had the highest rate (40.5 per 10,000 population, 95% CI: 35.1, 46.6). Conclusions: Adults with CHF had 8 times the rate of RSV-associated hospitalization compared with adults without CHF. Identifying high-risk populations for RSV infection can inform future RSV vaccination policies and recommendations. [ABSTRACT FROM AUTHOR]