학술논문
Long‐term effects of premenopausal risk‐reducing salpingo‐oophorectomy on cognition in women with high familial risk of ovarian cancer: A cross‐sectional study.
Document Type
Article
Author
Terra, Lara; Lee Meeuw Kjoe, Philippe R.; Agelink van Rentergem, Joost A.; Beekman, Maarten J.; Heemskerk‐Gerritsen, Bernadette A. M.; van Beurden, Marc; Roeters van Lennep, Jeanine E.; van Doorn, Helena C.; de Hullu, Joanna A.; Mourits, Marian J. E.; van Dorst, Eleonora B. L.; Mom, Constantijne H.; Slangen, Brigitte F. M.; Gaarenstroom, Katja N.; van der Kolk, Lizet E.; Collée, J. Margriet; Wevers, Marijke R.; Ausems, Margreet G. E. M.; van Engelen, Klaartje; van de Beek, Irma
Source
Subject
*OVARIAN cancer
*DISEASE risk factors
*SALPINGO-oophorectomy
*COGNITIVE testing
*CROSS-sectional method
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Language
ISSN
1470-0328
Abstract
Objective: To examine the effect of a premenopausal risk‐reducing salpingo‐oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. Design: A cross‐sectional study with prospective follow‐up, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population or Sample: 641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 (n = 436) or a postmenopausal RRSO ≥ age 54 (n = 205). All participants were older than 55 years at recruitment. Methods: Participants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression. Main Outcome Measures: The influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO. Results: After adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years). Conclusions: Reassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition. [ABSTRACT FROM AUTHOR]