학술논문
Transfusion management in the era of magrolimab (Hu5F9‐G4), an anti‐CD47 monoclonal antibody therapy.
Document Type
Article
Author
Source
Subject
*MONOCLONAL antibodies
*ERYTHROCYTES
*BLOOD platelets
*BLOOD grouping & crossmatching
*CANCER cells
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*
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Language
ISSN
0041-1132
Abstract
This article explores the challenges that arise in pretransfusion testing and blood typing due to the use of monoclonal antibody cancer therapies, specifically focusing on magrolimab (Hu5F9-G4). The therapy interferes with CD47, a protein expressed on cancer cells as well as red blood cells and platelets, which can lead to false-positive results in serological tests and difficulties in providing compatible blood for transfusions. The article also discusses the interference caused by another monoclonal antibody therapy, anti-CD38, and provides strategies to mitigate these issues. The article emphasizes the importance of effective communication and provides recommendations for managing the interference caused by magrolimab in clinical trials. [Extracted from the article]