학술논문
Nasopharyngeal carcinoma treated with bevacizumab combined with paclitaxel liposome plus cisplatin: a case report and literature review.
Document Type
Case Study
Author
Source
Subject
*NASOPHARYNX cancer
*BEVACIZUMAB
*PACLITAXEL
*CISPLATIN
*CANCER chemotherapy
*CANCER treatment
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Language
ISSN
1178-6930
Abstract
Patients with stage IV nasopharyngeal carcinoma (NPC) have a poor prognosis, even with effective chemotherapy. Target agents combined with chemotherapy may improve NPC patients' outcome. The case of a patient with NPC, who was treated by adding bevacizumab to chemotherapy after disease progression using first-line chemotherapy, is reported. Recently published literature about effects of combining bevacizumab with standard chemotherapy in NPC cell lines or patients are also reviewed and discussed. Consistent with a few preclinical trials and Phase II clinical trials, bevacizumab may reverse the drug resistance to chemotherapy, and its toxic side effects are well tolerated. [ABSTRACT FROM AUTHOR]