학술논문
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Document Type
Article
Author
Eeles, Rosalind A; Haiman, Christopher A; Schumacher, Fredrick; Henderson, Brian E; Ingles, Sue A; Le Marchand, Loic; Lindstrom, Sara; Kraft, Peter; Hunter, David J; Gapstur, Susan; Chanock, Stephen J; Berndt, Sonja I; Albanes, Demetrius; Andriole, Gerald; Schleutker, Johanna; Weischer, Maren; Canzian, Federico; Campa, Daniele; Olama, Ali Amin Al; Benlloch, Sara
Source
Subject
*PROSTATE cancer risk factors
*DISEASE susceptibility
*GENOTYPES
*LOCUS (Genetics)
*SINGLE nucleotide polymorphisms
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Language
ISSN
1061-4036
Abstract
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10−8). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies. [ABSTRACT FROM AUTHOR]