학술논문
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance
Document Type
Article
Author
Source
Subject
*CHEMOKINE receptors
*PHARMACOKINETICS
*PIPERIDINE
*AMIDES
*METABOLISM
*DRUG design
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Language
ISSN
0960-894X
Abstract
Abstract: The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H1 dual antagonists described in Part I. This involved further structural exploration directed at reducing metabolism and leading to the identification of compound 60 with a greatly improved in vivo pharmacokinetic profile. [Copyright &y& Elsevier]