학술논문
FVIII inhibitor development according to concentrate: data from the EUHASS registry excluding overlap with other studies.
Document Type
Article
Author
Fischer, K.; Iorio, A.; Hollingsworth, R.; Makris, M.; Watson, Henry; Rae, Joan; Platokouki, Helen; Pergantou, Helen; Katsarou, Olga; Theodossiades, George; Nomikou, Efrosyni; Parra, Rafael; Alonso, Sofia; Klamroth, Robert; Kubicek, Cornelia; Wilde, Jonathan; Dunkley, Tracey; Oldenburg, Johannes; Schmickler, Daniela; Ackroyd, Sam
Source
Subject
*HEMOPHILIA
*BLOOD coagulation factor VIII
*BLOOD coagulation disorders
*TITERS
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*
Language
ISSN
1351-8216
Abstract
The article presents a study which provides additional analyses of the data from the European Haemophilia Safety Surveillance System (EUHASS) study. It states that analysis of EUHASS study's non-overlapping data can offer information on the perceived increased inhibitor risk related with the use of specific recombinant Factor VIII concentrates in previously untreated patients. It is noted that patients with a titre equal or higher than 5 Bethesda unit were defined as high titre inhibitors.