부산대학교 도서관

A number of studies have indicated that 8p22-p12 is likely to harbor schizophrenia susceptibility loci. In this region, the candidate gene of interest, neuregulin 1 (NRG1), may play a role in the pathogenesis of schizophrenia. Then in the present study, we performed the linkage disequilibrium to determine the association between three genetic variants (SNPs: rs3924999, rs2954041, SNP8NRG221533) on NRG1 gene and schizophrenia in 246 Chinese Han schizophrenic family trios using PCR-based restriction fragment length polymorphism method and denaturing high-performance liquid chromatography. The transmission disequilibrium test analysis for each variant showed a significant difference between two transmitted alleles even after Bonferroni correction (rs3924999, P = 0.007752; rs2954041, P = 0.0009309; SNP8NRG221533, P= 0.012606). The global χ² test for haplotype transmission also revealed a strong association (χ² = 46.068, df = 7, P < 0.000001). Our results suggest that the NRG1 gene may play a role in conferring susceptibility to the disease. [ABSTRACT FROM AUTHOR]