학술논문
Palladium-Catalyzed/Copper-Mediated Desulfurization and Aryl--ation of Quinoline-2-(1 H)-thione for Rapid Access to Quinoline Derivatives.
Document Type
Article
Source
Subject
*QUINOLINE derivatives
*SCISSION (Chemistry)
*CARBON-carbon bonds
*DESULFURIZATION
*COUPLING reactions (Chemistry)
*ALKYNES
*QUINOLINE
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Language
ISSN
0039-7881
Abstract
An efficient method for carbon–carbon bond formation is described. The process employs the palladium-catalyzed and copper-mediated cross-coupling of quinoline-2-(1 H)-thiones with arylboronic acids or alkynes through C–S bond cleavage without an inert atmosphere. The method provides rapid and general access to a diverse range of 2-substituted quinolines in a single step from a wide range of quinoline-2-(1 H)-thiones and arylboronic acids or alkynes. [ABSTRACT FROM AUTHOR]