학술논문
Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR.
Document Type
Article
Author
Source
Subject
*DNA damage
*PROTEIN structure
*DETECTORS
*CANCER cells
*DNA structure
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Language
ISSN
0079-6107
Abstract
ATM, ATR and DNA-PKCs are key effectors of DNA Damage response and have been extensively linked to tumourigenesis and survival of cancer cells after radio/chemotherapy. Despite numerous efforts, the structures of these proteins remained elusive until very recently. The resolution revolution in Cryo-EM allowed for molecular details of these proteins to be seen for the first time. Here we provide a comprehensive review of the structures of ATM, ATR and DNA-PKcs and their complexes and expand with observations springing from our own cryo-EM studies. These observations include a novel conformation of ATR and novel dimeric arrangements of DNA-PKcs. [ABSTRACT FROM AUTHOR]