학술논문
PPARs as Key Transcription Regulators at the Crossroads of Metabolism and Inflammation.
Document Type
Article
Author
Source
Subject
*PEROXISOME proliferator-activated receptors
*METABOLISM
*NUCLEAR receptors (Biochemistry)
*INFLAMMATION
*INFLAMMATORY bowel diseases
*ADIPOGENESIS
*NON-alcoholic fatty liver disease
*PREGNANE X receptor
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Language
ISSN
1661-6596
Abstract
This article discusses the role of peroxisome proliferator-activated receptors (PPARs) in the regulation of metabolism and inflammation. PPARs are transcription factors that play a crucial role in energy metabolism and immune response. They are involved in gene expression changes that respond to signals from both inside and outside the cell. Dysfunctions in PPARs have been associated with the development of metabolic diseases. The article highlights the specific roles of each PPAR isotype (PPARα, PPARβ/δ, and PPARγ) in various metabolic diseases and inflammation. It also mentions the potential therapeutic applications of PPAR agonists in the treatment of these conditions. The article emphasizes the complexity of PPAR functions and the need for further research to fully understand their roles in healthy and diseased organisms. [Extracted from the article]