학술논문
PPARs as Key Mediators in the Regulation of Metabolism and Inflammation.
Document Type
Article
Author
Source
Subject
*METABOLIC regulation
*NUCLEAR receptors (Biochemistry)
*AP-1 transcription factor
*STEROID receptors
*BRAIN-derived neurotrophic factor
*PEROXISOME proliferator-activated receptors
*PURINERGIC receptors
*CANNABINOID receptors
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Language
ISSN
1661-6596
Abstract
The development of synthetic PPAR ligands and new PPAR binding assays that may help to establish alternative therapeutics with reduced side effects for metabolic and inflammatory diseases has been a promising recurrent activity over the last 25 years. In fact, all three PPAR isotypes (PPAR , PPAR / , and PPAR ) demonstrate anti-inflammatory capacities. Using the specific PPAR modulator (SPPARM ) pemafibrate (K-877), which selectively and potently activates PPAR , Lee et al. [[12]] found that, in addition to stimulating liver function that results in elevated serum levels of fibroblast growth factor 21 (FGF21), a neuroprotective hormone in the eye, PPAR also protects against retinal impairment induced by unilateral common carotid artery occlusion. Nuclear receptors (NRs) form a large family of ligand-dependent transcription factors that control the expression of a multitude of genes involved in diverse, vital biological processes. [Extracted from the article]