학술논문
Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application.
Document Type
Article
Author
Source
Subject
*BETA adrenoceptors
*G proteins
*ADENYLATE cyclase
*HEART failure
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Language
ISSN
0008-6312
Abstract
β-Adrenergic receptors (β-AR) are central to the overall regulation of cardiac function. From the first proposed receptor/transmitter concept to the latest clinical β-blocker trials β-AR have been shown to play an important role in cardiac disease and heart failure in particular. This study provides a historical perspective, reviews the latest discoveries and beliefs, and discusses the current clinical practices of β-AR and their modulation with their associated guanine-nucleotide regulatory protein/adenylylcyclasesignal transduction pathways. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]