학술논문
DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.
Document Type
Article
Author
Source
Subject
*DNA damage
*DOXORUBICIN
*P53 antioncogene
*
*
Language
ISSN
0950-9232
Abstract
Shows that, in response to a non apoptotic DNA damage induced by low doses of doxorubicin, p53 binds in vivo, as detected by a p53-specific chromatin immunoprecipitation assay, and activates the P2-p73 promoter. Effect of unchecked DNA damage on S phase and mitosis; Factors that influence the choice between cell cycle arrest and apoptosis; Role of DNp73 proteins in the cellular responses to DNA damage.