부산대학교 도서관

Aberrant brain network development represents a putative aetiological component in mental disorders, which typically emerge during childhood and adolescence. Previous studies have identified resting‐state functional connectivity (RSFC) patterns reflecting psychopathology, but the generalisability to other samples and politico‐cultural contexts has not been established. We investigated whether a previously identified cross‐diagnostic case–control and autism spectrum disorder (ASD)‐specific pattern of RSFC (discovery sample; aged 5–21 from New York City, USA; n = 1666) could be validated in a Norwegian convenience‐based youth sample (validation sample; aged 9–25 from Oslo, Norway; n = 531). As a test of generalisability, we investigated if these diagnosis‐derived RSFC patterns were sensitive to levels of symptom burden in both samples, based on an independent measure of symptom burden. Both the cross‐diagnostic and ASD‐specific RSFC pattern were validated across samples. Connectivity patterns were significantly associated with thematically appropriate symptom dimensions in the discovery sample. In the validation sample, the ASD‐specific RSFC pattern showed a weak, inverse relationship with symptoms of conduct problems, hyperactivity and prosociality, while the cross‐diagnostic pattern was not significantly linked to symptoms. Diagnosis‐derived connectivity patterns in a developmental clinical US sample were validated in a convenience sample of Norwegian youth, however, they were not associated with mental health symptoms. [ABSTRACT FROM AUTHOR]