학술논문
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Document Type
Article
Author
Mercken, Evi M.; Mitchell, Sarah J.; Martin‐Montalvo, Alejandro; Minor, Robin K.; Almeida, Maria; Gomes, Ana P.; Scheibye‐Knudsen, Morten; Palacios, Hector H.; Licata, Jordan J.; Zhang, Yongqing; Becker, Kevin G.; Khraiwesh, Husam; González‐Reyes, José A.; Villalba, José M.; Baur, Joseph A.; Elliott, Peter; Westphal, Christoph; Vlasuk, George P.; Ellis, James L.; Sinclair, David A.
Source
Subject
*GENE expression
*LIFE spans
*SMALL molecules
*LABORATORY mice
*BONE density
*INSULIN resistance
*INFLAMMATION
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Language
ISSN
1474-9718
Abstract
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. These results demonstrate it is possible to design a small molecule that can slow aging and delay multiple age-related diseases in mammals, supporting the therapeutic potential of SIRT1 activators in humans. [ABSTRACT FROM AUTHOR]