부산대학교 도서관

Experimental allergic encephalomyelitis (EAE) was induced with equal incidence in groups of rats regardless of whether the route of brain vaccine injection was intracutaneous and into hind foot pads or intraperitoneal. Rats which were injected intracutaneously and into hind foot pads either developed EAE within 10–16 days or showed signs of what we have termed ‘adjuvant disease’. Intraperitoneally injected animals that failed to develop demyelinating disease showed almost diffuse proliferative peritonitis, but those with EAE had a more circumscribed granulomatous proliferation in the upper part of abdomen. Suppression of EAE was obtained when the oily suspension of mycobacteria without brain was injected intraperitoneally within 11 days after the inoculation of brain in adjuvant mixture intradermally and into foot pads. No suppression of EAE was seen when adjuvant alone was injected intraperitoneally 12 or 14 days after brain in adjuvant mixture. The results are discussed in terms of a hypothesis based on the competition of antigens. [ABSTRACT FROM AUTHOR]