부산대학교 도서관

It is undeniable that music and sounds can affect our emotions and mood, but so far the study of physical stimuli provoked by sound on living organisms has been mostly focused on brain and sensorimotor structures rather than cellular metabolism. Using metabolomics, we compared the physiology of yeast cells growing in defined liquid medium exposed to music, high and low frequency sonic vibration and silence. All sonic stimuli tested not only increased the growth rate of the yeast cells by 12% but they also reduced biomass production by 14%. The intra- and extracellular metabolite profiles differed significantly depending on the sonic stimulus applied showing that different metabolic pathways are affected differently by different sound frequency. Therefore, our results clearly demonstrate that sound does affect microbial cell metabolism when growing in liquid culture, opening an entirely new perspective for scientific investigation interfacing acoustics, biophysics and biochemistry. [ABSTRACT FROM AUTHOR]