학술논문
Nitroepoxides as Versatile Precursors to 1,4-DiaminoHeterocycles.
Document Type
Article
Source
Subject
*EPOXY compounds
*CHEMICAL precursors
*HETEROCYCLIC compounds
*PYRAZINES
*DIAMINES
*QUINOXALINES
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Language
ISSN
1523-7060
Abstract
Nitroepoxidesare easily transformed into 1,4-diamino heterocyclessuch as quinoxalines and pyrazines by treatment with 1,2-benzenediaminesand ammonia, respectively. Additionally, related saturated heterocycles,such as piperazines and tetrahydroquinoxalines, can be accessed bytreatment with 1,2-diamines and a reducing agent. These transformationsare efficient, provide access privileged, bioactive structures, andproduce minimal waste. [ABSTRACT FROM AUTHOR]