학술논문
Influence of sex, age, pubertal maturation and body mass index on circulating white blood cell counts in healthy European adolescents-the HELENA study.
Document Type
Article
Author
Pérez-de-Heredia, Fátima; Gómez-Martínez, Sonia; Díaz, Ligia-Esperanza; Veses, Ana; Nova, Esther; Wärnberg, Julia; Huybrechts, Inge; Vyncke, Krishna; Androutsos, Odysseas; Ferrari, Marika; Palacios, Gonzalo; Wastlund, Acki; Kovács, Éva; Gottrand, Frédéric; González-Gross, Marcela; Castillo, Manuel; Sjöstrom, Michael; Manios, Yannis; Kafatos, Anthony; Molnár, Denes
Source
Subject
*LEUKOCYTE count
*BODY mass index
*PUBERTY
*PERCENTILES
*NEUTROPHILS
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Language
ISSN
0340-6199
Abstract
Percentiles 10th, 25th, 50th, 75th and 90th are presented for circulating white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils and basophils in healthy European adolescents (12.5-17.5 years, n = 405, 48.9 % boys), considering age, sex, puberty and body mass index (BMI). CD3 (mature T cells), CD4 (T helper), CD8 (T cytotoxic), CD1656 (natural killer), CD19 (B cells), CD3CD45RA, CD4CD45RA, CD8CD45RA (naïve), CD3CD45RO, CD4CD45RO and CD8CD45RO (memory) lymphocytes were also analysed by immunophenotyping. Girls presented higher WBC, neutrophil, CD3CD45RO and CD4CD45RO cell counts and CD3/CD19 ratio, and lower CD3CD45RA and CD4CD45RA counts than boys. Age was associated with higher neutrophil counts and CD3/CD19, and lower CD19 counts; in boys, with lower CD3CD45RA, CD4CD45RA and CD8CD45RA counts as well; in girls, with higher WBC, CD3CD45RO and CD4CD45RO counts. Pubertal maturation in boys was associated with lower WBC and lymphocyte counts; in girls, with higher basophil, CD3CD45RO and CD4CD45RO values. BMI was associated with higher WBC counts; in boys, also with higher lymphocyte counts; in girls, with higher neutrophil, CD4, CD3CD45RO and CD4CD45RO counts. Conclusion: Our study provides normative values for circulating immune cells in adolescents, highlighting the importance of considering sex, age, pubertal maturation and BMI when establishing reference ranges for WBC in paediatric populations. [ABSTRACT FROM AUTHOR]