학술논문
Two tyrosine residues in the first transmembrane helix of the human vasoactive intestinal peptide receptors play a role in supporting the active conformation.
Document Type
Article
Author
Source
Subject
*VASOACTIVE intestinal peptide
*PEPTIDE hormones
*TYROSINE
*
*
Language
ISSN
0007-1188
Abstract
Investigates the human vasoactive intestinal polypeptide (VIP) receptors VPAC [sub 1] and VPAC [2] mutated at conserved tyrosine residues int he first transmembrane helix. VPAC [sub 1] binding sites that displayed high and low affinities for VIP; Potency of VIP at the Y130A and Y134A mutated VPAC [sub 2] receptors; Interaction of the conserved tyrosine residues with the VIP.