부산대학교 도서관

Background: To test the hypothesis that varicella-zoster virus (VZV) infection contributes to temporal arteritis pathogenesis, comprehensive in situ analysis was performed on temporal artery biopsies of 38 anterior ischemic optic neuropathy (AION) patients, including 14 (37%) with giant cell arteritis.Methods: Biopsies were completely sectioned, and, on average, 146 serial sections per patient were stained for VZV glycoprotein E.Results: Four of 38 AION patients showed VZV glycoprotein E staining, but VZV infection was not confirmed by staining for VZV IE63 protein and VZV-specific polymerase chain reaction on adjacent sections.Conclusions: This study refutes the premise that VZV is casually related to AION with and without giant cell arteritis. [ABSTRACT FROM AUTHOR]