학술논문
SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts.
Document Type
Article
Source
Subject
*SARS-CoV-2
*EMBRYOLOGY
*CONFOCAL microscopy
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Language
ISSN
1058-0468
Abstract
Purpose: To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts. Methods: Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research. Results: SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma. Conclusion: Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]