학술논문
The Influence of Personalised Sarcoma Care (PERSARC) Prediction Modelling on Clinical Decision Making in a Multidisciplinary Setting.
Document Type
Article
Author
Hagenmaier, H. S. Femke; van Beeck, Annelies G. K.; Haas, Rick L.; van Praag, Veroniek M.; van Bodegom-Vos, Leti; van der Hage, Jos A.; Krol, Stijn; Speetjens, Frank M.; Cleven, Arjen H. G.; Navas, Ana; Kroon, Herman M.; Moeri-Schimmel, Rieneke G.; Leyerzapf, Nicolette A. C.; van de Sande, Michiel A. J.
Source
Subject
*EXTREMITIES (Anatomy)
*PATIENT-centered care
*CANCER relapse
*HEALTH care teams
*DECISION making
*DESCRIPTIVE statistics
*SURVIVAL analysis (Biometry)
*DECISION making in clinical medicine
*PREDICTION models
*SARCOMA
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Language
ISSN
1357-714X
Abstract
Background. With soft-tissue sarcoma of the extremity (ESTS) representing a heterogenous group of tumors, management decisions are often made in multidisciplinary team (MDT) meetings. To optimize outcome, nomograms are more commonly used to guide individualized treatment decision making. Purpose. To evaluate the influence of Personalised Sarcoma Care (PERSARC) on treatment decisions for patients with high-grade ESTS and the ability of the MDT to accurately predict overall survival (OS) and local recurrence (LR) rates. Methods. Two consecutive meetings were organised. During the first meeting, 36 cases were presented to the MDT. OS and LR rates without the use of PERSARC were estimated by consensus and preferred treatment was recorded for each case. During the second meeting, OS/LR rates calculated with PERSARC were presented to the MDT. Differences between estimated OS/LR rates and PERSARC OS/LR rates were calculated. Variations in preferred treatment protocols were noted. Results. The MDT underestimated OS when compared to PERSARC in 48.4% of cases. LR rates were overestimated in 41.9% of cases. With the use of PERSARC, the proposed treatment changed for 24 cases. Conclusion. PERSARC aids the MDT to optimize individualized predicted OS and LR rates, hereby guiding patient-centered care and shared decision making. [ABSTRACT FROM AUTHOR]