학술논문
Progressive multifocal leukoencephalopathy following chemotherapy for lung cancer.
Document Type
Article
Author
Source
Subject
*PROGRESSIVE multifocal leukoencephalopathy
*LUNG cancer
*CANCER chemotherapy
*CNS demyelinating autoimmune diseases
*HEMATOLOGY
*IMMUNOREGULATION
*HIV infections
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Language
ISSN
1590-1874
Abstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus infection and with a frequent lethal outcome. PML usually occurs in immunocompromised subjects, such as HIV-positive individuals, as well as in other conditions characterized by depletion of cellular immunity, including hematological malignancies, autoimmune diseases, and immunomodulatory therapies. We describe the case of a 76-year-old man affected by advanced non-small cell lung cancer who developed PML after six cycles of carboplatin/gemcitabine therapy, during which a transitory leucopenia developed. The patient deceased a few months after the onset of the symptoms. Chemotherapy appears to be uncommon, but definite condition associated to PML. [ABSTRACT FROM AUTHOR]