부산대학교 도서관

Background: A diagnostic work-up leading to a lung cancer diagnosis is a severely stressful experience that may impact tumor progression. Yet, prospective data are scarce on psychological and biological components of stress at the time of lung cancer diagnosis. The aim of this study was to assess pre-to-post diagnosis change in psychological distress and urinary excretion of catecholamines in patients with suspected lung cancer. Methods: Participants were 167 patients within the LUCASS study, recruited at referral for suspected lung cancer to University Hospitals in Iceland and Sweden. Patients completed questionnaires on perceived distress (Hospital Anxiety and Depression Scale, HADS) before and after diagnosis of lung cancer or a non-malignant origin. A subpopulation of 85 patients also provided overnight urine for catecholamine analysis before and at a median of 24 days after diagnosis but before treatment. Results: A lung cancer diagnosis was confirmed in 123 (73.7%) patients, with a mean age of 70.1 years. Patients diagnosed with lung cancer experienced a post-diagnosis increase in psychological distress (p=0.010), while patients with non-malignant lung pathology showed a reduction in distress (p=0.070). Both urinary epinephrine (p=0.001) and norepinephrine (p=0.032) levels were higher before the diagnosis among patients eventually diagnosed with lung cancer compared to those with non-malignant lung pathology. We observed indications of associations between pre-to-post diagnosis changes in perceived distress and changes in urinary catecholamine levels. Conclusion: Receiving a lung cancer diagnosis is associated with an increase in psychological distress, while elevated catecholamine levels are evident already before lung cancer diagnosis. Abbreviations: HADS: Hospital Anxiety and Depression scale; HADS-A: Hospital Anxiety and Depression scale - anxiety score; HADS-D: Hospital Anxiety and Depression scale - depression score; HADS-T: Hospital Anxiety and Depression scale - total score; IQR: Interquartile range; LUCASS study: Lung Cancer, Stress and Survival study; NSCLC: Non-small cell lung cancer; PTSD: Post Traumatic Stress Disorder; SCLC: Small-cell lung cancer; SD: Standard Deviation; SNS: the Sympathetic Nervous System. [ABSTRACT FROM AUTHOR]