학술논문
The Effects of Female Sex Hormones on Ventricular Premature Beats and Repolarization Parameters in Physiological Menstrual Cycle.
Document Type
Article
Author
Source
Subject
*ACADEMIC medical centers
*ACTION potentials
*ARRHYTHMIA
*ECHOCARDIOGRAPHY
*ESTRADIOL
*FISHER exact test
*HEART beat
*MENSTRUATION
*NONPARAMETRIC statistics
*OVULATION
*PROBABILITY theory
*PROGESTERONE
*T-test (Statistics)
*DATA analysis
*CASE-control method
*DATA analysis software
*VENTRICULAR outflow obstruction
*DESCRIPTIVE statistics
*MANN Whitney U Test
*DISEASE complications
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Language
ISSN
0147-8389
Abstract
Background The effects of gender difference on cardiac electrophysiology have been well studied. In this study, we aimed to evaluate the effects of estradiol and progesteron changes occuring in physiological menstrual cycle on ventricular premature beats (VPBs) and cardiac repolarization parameters. Methods Women of reproductive age with VPBs were included into the study group and healthy women were recruited as the control group. During the menstruation period, a 12-lead electrocardiography, blood samples, and 24-hour rhythm Holter were applied to the study group. Similarly, all tests were repeated in the estimated ovulation period (12-14 days before menstruation) by all cases. Results The study group consisted of 20 women patients with VPB, and the control group of 18 healthy women. While the number of VPB in the menstruation period was 210 beats/day (interquartile range [IQR]: 1,144), it decreased to 86 beats/day (IQR: 251) in the ovulation period with statistical significance (P < 0.05). Average heart rate in the menstruation period was 81.4 ± 10 beats/min and it significantly increased to 84.6 ± 8 beats/min in the ovulation period (P < 0.05). There were no differences in cardiac repolarization parameters in both menstruation and ovulation periods between the study and control groups. Comparing the menstruation and the ovulation periods, J-Tpeak interval, which reflects early repolarization, was shorter in the ovulation period (193 ± 27.7 ms and 201.1 ± 28.6 ms, respectively; P < 0.05). Other repolarization parameters did not show any significant difference. Conclusion VPB frequency decreases with estradiol peak in the ovulation period. This suggests that estrogen may have protective effects against ventricular arrhythmias. [ABSTRACT FROM AUTHOR]