부산대학교 도서관

Melorheostosis, also known as Leri-Joanny disease, is a rare skeletal dysplasia characterized by areas of bone sclerosis that resemble dripping candle wax. It typically manifests in infancy or adolescence and can lead to joint contractures and deformities. The condition is caused by somatic mutations in certain genes. Symptoms include localized pain, stiffness, limited range of motion, and limb swelling. Treatment focuses on pain control, but more severe cases may require surgery and bisphosphonates. This case study highlights the significant changes in bone and soft tissue that can be observed on radiographs. [Extracted from the article]