학술논문
Synthesis of N-Arylsulfonyl-α-thienylglycines from N-(2,2,2-Trichloro-1-thienylethyl)arenesulfonamides.
Document Type
Article
Source
Subject
*SULFONAMIDES
*TRICHLOROETHANE
*ORGANOCHLORINE compounds
*THIOPHENES
*CHEMICAL reactions
*HYDROLYSIS
*AMIDES
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Language
ISSN
1070-4280
Abstract
Reactions of N-(2,2,2-trichloroethylidene)arenesulfonamides with thiophene, 2-chlorothiophene, and 2,5-dichlorothiophene, as well as of N-(2,2,2-trichloro-1-hydroxyethyl)arenesulfonamides with 2-chlorothiophene, lead to formation of the corresponding N-(2,2,2-trichloro-1-thienylethyl)arenesulfonamides. Alkaline hydrolysis of the latter occurs selectively at the trichloromethyl group to give N-arylsulfonyl-α-thienylglycines. [ABSTRACT FROM AUTHOR]