학술논문
Association of the pre-transplant CD4/CD8 ratio with the prognosis following allogeneic hematopoietic stem cell transplantation.
Document Type
Article
Author
Nagayama, Takashi; Fujiwara, Shin-ichiro; Tominaga, Ryutaro; Yokoyama, Daizo; Noguchi, Atsuto; Furuki, Shuka; Oyama, Takashi; Koyama, Shunsuke; Murahashi, Rui; Nakashima, Hirotomo; Ikeda, Takashi; Hyodo, Kazuki; Kawaguchi, Shin-ichiro; Toda, Yumiko; Umino, Kento; Minakata, Daisuke; Morita, Kaoru; Ashizawa, Masahiro; Yamamoto, Chihiro; Hatano, Kaoru
Source
Subject
*HEMATOPOIETIC stem cell transplantation
*OVERALL survival
*HEMATOLOGIC malignancies
*MULTIVARIATE analysis
*TUMOR microenvironment
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Language
ISSN
1042-8194
Abstract
The tumor microenvironment's cells can promote or inhibit tumor formation, and there are no reports on the CD4/CD8 ratio's association with outcomes post allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively evaluated the pre-transplant peripheral blood CD4/CD8 ratio in 168 patients who underwent their first allo-HSCT for hematological malignancies at our institution. When patients were divided into two groups according to the median CD4/CD8 ratio 1.35 (range, 0.09–19.89), the high CD4/CD8 ratio group had a higher incidence of relapse, equivalent non-relapse mortality and worse overall survival (OS) than the low CD4/CD8 ratio group. In a multivariate analysis, the CD4/CD8 ratio was significantly associated with an increased risk of relapse, although there was a marginally significant difference in OS. The pre-transplant peripheral blood CD4/CD8 ratio could be a novel biomarker for predicting the prognosis of allo-HSCT. [ABSTRACT FROM AUTHOR]