부산대학교 도서관

Similarly, after the application of the irritant phorbol 12-myristate 13-acetate (PMA), the cutaneous responses were greater in I IRF3 i KO mice than in WT mice (Figure S2). Keywords: contact dermatitis; innate immunity; interferon regulatory factor 3; interleukin 33; regulatory T cell EN contact dermatitis innate immunity interferon regulatory factor 3 interleukin 33 regulatory T cell 715 717 3 05/03/23 20230501 NES 230501 Abbreviations used ACD allergic contact dermatitis ICD irritant contact dermatitis IL interleukin IRF3 interferon regulatory factor 3 KO knockout LPS lipopolysaccharide PMA phorbol 12-myristate 13-acetate PolyI C: polyinosinic:polycytidylic acid TGF- transforming growth factor- TLR toll-like receptor TNCB 2,4,6-trinitro-1-chlorobenzene Treg regulatory T cell WT wild-type Interferon regulatory factor 3 (IRF3) acts as a transcriptional regulator of cellular responses in several cell types and is involved in innate immunity, including Toll-like receptor (TLR) signalling. In this study, we examined the roles of IRF3 in skin inflammation by applying a hapten/stimulant to the skin of IRF3-deficient mice. [Extracted from the article]