부산대학교 도서관

This article discusses the factors that contribute to the development of severe asthma characterized by airway eosinophilia. It explains that patients with severe asthma may require high-dose inhaled corticosteroids (ICS) and sometimes even daily oral corticosteroids (OCS) to achieve asthma control. However, despite optimized corticosteroid therapy, asthma may remain uncontrolled and manifest as severe disease. The article highlights the role of neutrophil-predominant airway inflammation and steroid resistance as key characteristics of severe asthma. It also mentions other factors such as late reactions after allergen challenge, elevated type-2 markers, chronic rhinosinusitis with nasal polyposis, and environmental exposures that contribute to the severity of asthma. The authors emphasize the importance of recognizing severe asthma early to gain better control of symptoms and prevent further damage to the airways. [Extracted from the article]