학술논문
Alternative polyadenylation in the regulation and dysregulation of gene expression.
Document Type
Article
Source
Subject
*NUCLEOTIDES
*MOLECULAR genetics
*FIBROBLASTS
*GENE expression
*TRANSCRIPTION factors
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Language
ISSN
1084-9521
Abstract
Transcriptional control shapes a cell’s transcriptome composition, but it is RNA processing that refines its expression. The untranslated regions (UTRs) of mRNA are hotspots for regulatory control. Features in these can impact mRNA stability, localisation and translation. Here we describe how alternative cleavage and polyadenylation can change mRNA fate by changing the length of its 3’UTR. [ABSTRACT FROM AUTHOR]